BIOMAT Database Logo BIOMAT Database Logo

Resistance of domestic cats to a US sheep scrapie agent by intracerebral route. 2002

Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA.

Feline spongiform encephalopathy (FSE) is thought to have resulted from consumption of food contaminated with bovine spongiform encephalopathy and the latter is believed to result from the consumption of food contaminated with scrapie. However, no direct experimental documentation exists to indicate that the scrapie agent is capable of amplifying in cats, and, therefore, crossing the species barrier. During 1979, 6 cats ranging in age from 3.5 to 18 months were intracerebrally inoculated with sheep scrapie (inoculum G-639-PP) and were observed for an extended period. Inoculated cats did not develop neurologic disease, and microscopic lesions of spongiform encephalopathy were not evident. Immunohistochemistry and Western blot techniques failed to detect the abnormal form of prion protein (PrP(res)). These results indicate that the sheep scrapie agent (G-639-PP) used in this study was not capable of amplifying in cats and therefore was unable to cross the species barrier to produce FSE.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D008297 Male Males
D002371 Cat Diseases Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used. Feline Diseases,Cat Disease,Disease, Cat,Disease, Feline,Diseases, Cat,Diseases, Feline,Feline Disease
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012757 Sheep Diseases Diseases of domestic and mountain sheep of the genus Ovis. Ovine Diseases,Disease, Ovine,Disease, Sheep,Diseases, Ovine,Diseases, Sheep,Ovine Disease,Sheep Disease
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species
D014481 United States A country in NORTH AMERICA between CANADA and MEXICO.

Related Publications

Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculation.
January 2008, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
White-tailed deer are susceptible to the agent of sheep scrapie by intracerebral inoculation.
October 2011, Veterinary research,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Resistance of cattle to scrapie by the oral route.
April 2001, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep.
January 2008, Veterinary pathology,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Efficient transmission of classical scrapie agent x124 by intralingual route to genetically susceptible sheep with a low dose inoculum.
October 2020, Research in veterinary science,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Resistance of scrapie agent to decontamination.
December 1978, The New England journal of medicine,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Resistance of the scrapie agent to inactivation by psoralens.
May 1983, Photochemistry and photobiology,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Failure to detect abnormal prion protein and scrapie-associated fibrils 6 wk after intracerebral inoculation of genetically susceptible sheep with scrapie agent.
October 2002, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
RESISTANCE OF THE SCRAPIE AGENT TO FORMALIN.
April 1965, Journal of comparative pathology,
Amir N Hamir, and Wilber W Clark, and Diane L Sutton, and Janice M Miller, and Mick J Stack, and Melanie J Chaplin, and Allen L Jenny
Breeding German sheep for resistance to scrapie.
February 2004, The Veterinary record,
Copied contents to your clipboard!