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[The utility of high density lipoprotein cholesterol subclasses measurement]. 2002

Anna Skoczyńska, and Barbara Turczyn, and Małgorzata Kuliszkiewicz-Janus, and Arkadiusz Derkacz, and Rafał Poreba
Katedra i Klinika Chorób Wewnetrznych, Zawodowych i Nadciśnienia Tetniczego AM we Wrocławiu.

The aim of our study was to estimate the cholesterol concentrations in high density lipoprotein subfractions (HDL2 i HDL3) in plasma of patients with normocholesterolemia and atherosclerosis of coronary arteries and in patients with myeloproliferative diseases. Blood samples from patients with normal plasma cholesterol levels were analyzed in spite of the fact that atherosclerosis of coronary arteries usually exist with hypercholesterolemia and myeloproliferative diseases usually coexist with hypocholesterolemia. In this way we wanted to determine changes in HDL2 i HDL3 metabolism which occur independently from changes of cholesterol levels in other lipoproteins. Our results showed that in patients suffering from atherosclerosis of coronary arteries with normolipemia the lowering of plasma cholesterol level in subfractions HDL2 and HDL3 was observed. In patients with myeloproliferative disease with normocholesterolemia the slight lowering of cholesterol level in subfraction HDL3 may be connected with moderate hypertriglyceridemia. In both groups of patients the lowering of HDL cholesterol in plasma was accompanied with the increased lipid peroxidation.

UI MeSH Term Description Entries
D008075 Lipoproteins, HDL A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases. High Density Lipoprotein,High-Density Lipoprotein,High-Density Lipoproteins,alpha-Lipoprotein,alpha-Lipoproteins,Heavy Lipoproteins,alpha-1 Lipoprotein,Density Lipoprotein, High,HDL Lipoproteins,High Density Lipoproteins,Lipoprotein, High Density,Lipoprotein, High-Density,Lipoproteins, Heavy,Lipoproteins, High-Density,alpha Lipoprotein,alpha Lipoproteins
D008078 Cholesterol, LDL Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol. LDL Cholesterol,Cholesteryl Linoleate, LDL,LDL Cholesteryl Linoleate,Low Density Lipoprotein Cholesterol,beta-Lipoprotein Cholesterol,Cholesterol, beta-Lipoprotein,beta Lipoprotein Cholesterol
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009196 Myeloproliferative Disorders Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE. Disorder, Myeloproliferative,Disorders, Myeloproliferative,Myeloproliferative Disorder
D003324 Coronary Artery Disease Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause. Arteriosclerosis, Coronary,Atherosclerosis, Coronary,Coronary Arteriosclerosis,Coronary Atherosclerosis,Left Main Coronary Artery Disease,Left Main Coronary Disease,Left Main Disease,Arterioscleroses, Coronary,Artery Disease, Coronary,Artery Diseases, Coronary,Atheroscleroses, Coronary,Coronary Arterioscleroses,Coronary Artery Diseases,Coronary Atheroscleroses,Left Main Diseases
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

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