BIOMAT Database Logo BIOMAT Database Logo

Effects of Chlorella vulgaris extract on cytokines production in Listeria monocytogenes infected mice. 2002

Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Departamento de Farmacologia/Hemocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. msq44@uol.com.br

In this study, we have investigated the effects of the unicellular-green-algae Chlorella vulgaris on the production of INF-gamma, IL-2, IL-4 and IL-10 in normal and Listeria monocytogenes infected mice. Our results demonstrated that in normal/non infected mice, CVE administration produced no effects in the levels of all cytokines studied. However, Listeria monocytogenes infection enhanced the production of INF-gamma and IL-2 at 48 and 72 h after the bacteria inoculation. Interestingly, the treatment with five consecutive doses of 50 mg/Kg/day of Chlorella vulgaris given previously to infection, led to further increases in INF-gamma and IL-2 levels at 48 and 72 h in relation to the presence of infection alone. No changes in IL-4 and IL-10 production were observed in Listeria monocytogenes and CVE treated/infected mice. These results are in accordance with the literature, which shows that CVE is a biological response modifier that enhances resistance to Listeria monocytogenes through augmentation of IL-2 and IFN-gamma.

UI MeSH Term Description Entries
D007155 Immunologic Factors Biologically active substances whose activities affect or play a role in the functioning of the immune system. Biological Response Modifier,Biomodulator,Immune Factor,Immunological Factor,Immunomodulator,Immunomodulators,Biological Response Modifiers,Biomodulators,Factors, Immunologic,Immune Factors,Immunological Factors,Modifiers, Biological Response,Response Modifiers, Biological,Factor, Immune,Factor, Immunological,Factors, Immune,Factors, Immunological,Modifier, Biological Response,Response Modifier, Biological
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008088 Listeriosis Infections with bacteria of the genus LISTERIA. Listeria Infections,Infections, Listeria,Infection, Listeria,Listeria Infection,Listerioses
D008297 Male Males
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D002708 Chlorella Nonmotile unicellular green algae potentially valuable as a source of high-grade protein and B-complex vitamins. Chlorellas
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015847 Interleukin-4 A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells. B-Cell Growth Factor-I,B-Cell Stimulatory Factor-1,Binetrakin,IL-4,Mast Cell Growth Factor-2,B Cell Stimulatory Factor-1,B-Cell Growth Factor-1,B-Cell Proliferating Factor,B-Cell Stimulating Factor-1,B-Cell Stimulatory Factor 1,BCGF-1,BSF-1,IL4,MCGF-2,B Cell Growth Factor 1,B Cell Growth Factor I,B Cell Proliferating Factor,B Cell Stimulating Factor 1,B Cell Stimulatory Factor 1,Interleukin 4,Mast Cell Growth Factor 2
D016207 Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. Cytokine
D016753 Interleukin-10 A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein. IL-10,CSIF-10,Cytokine Synthesis Inhibitory Factor,IL10,Interleukin 10

Related Publications

Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Effects of Chlorella vulgaris on bone marrow progenitor cells of mice infected with Listeria monocytogenes.
August 1999, International journal of immunopharmacology,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
The effects of Chlorella vulgaris in the protection of mice infected with Listeria monocytogenes. Role of natural killer cells.
August 1999, Immunopharmacology and immunotoxicology,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice.
May 1994, Immunopharmacology and immunotoxicology,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes.
January 1997, Immunopharmacology,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses.
June 1995, International journal of immunopharmacology,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Prophylactic administration of Withania somnifera extract increases host resistance in Listeria monocytogenes infected mice.
October 2006, International immunopharmacology,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Survival of Listeria monocytogenes in experimentally infected mice.
January 1971, Applied microbiology,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Plasma enzyme changes in Listeria monocytogenes-infected mice.
December 1967, The Journal of infectious diseases,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Less polar ginsenosides have better protective effects on mice infected by Listeria monocytogenes.
April 2021, Ecotoxicology and environmental safety,
Mary L S Queiroz, and Claudia Bincoletto, and Marize C Valadares, and Denise C M Dantas, and Leonilda M B Santos
Effect of splenectomy on production of interferon and colony-stimulating factor in Listeria monocytogenes-infected mice.
December 1984, Infection and immunity,
Copied contents to your clipboard!