BIOMAT Database Logo BIOMAT Database Logo

Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses. 1995

T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Laboratory of Host Defense and Germfree Life, Nagoya University School of Medicine, Japan.

The bacterial elimination after infection with Listeria monocytogenes was impaired in mice with murine acquired immunodeficiency syndrome (MAIDS) by infection with LP-BM5 murine leukemia virus. Oral administration of hot water extracts of Chlorella vulgaris (CVE) restored the capacity of MAIDS mice to eliminate L. monocytogenes in association with improvement of the deteriorated immune response to L. monocytogenes. DTH response to Listeria in CVE-treated MAIDS mice was significantly higher than that of MAIDS mice after Listeria infection in association with increases in number of CD4+CD8- and CD4-CD8+ alpha beta T-cells in the infected sites. CVE might be effective in the treatment of opportunistic infection in retrovirus-induced immunodeficient patients.

UI MeSH Term Description Entries
D006968 Hypersensitivity, Delayed An increased reactivity to specific antigens mediated not by antibodies but by sensitized T CELLS. Hypersensitivity, Tuberculin-Type,Hypersensitivity, Type IV,Tuberculin-Type Hypersensitivity,Type IV Hypersensitivity,Delayed Hypersensitivity,Delayed Hypersensitivities,Hypersensitivity, Tuberculin Type,Tuberculin Type Hypersensitivity,Tuberculin-Type Hypersensitivities,Type IV Hypersensitivities
D007942 Leukemia, Experimental Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues. Experimental Leukemia,Experimental Leukemias,Leukemia Model, Animal,Leukemias, Experimental,Animal Leukemia Model,Animal Leukemia Models,Leukemia Models, Animal
D008088 Listeriosis Infections with bacteria of the genus LISTERIA. Listeria Infections,Infections, Listeria,Infection, Listeria,Listeria Infection,Listerioses
D008089 Listeria monocytogenes A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion.
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009052 Leukemia Virus, Murine Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. Graffi Virus,Graffi's Chloroleukemic Strain,Leukemia Viruses, Murine,Mouse Leukemia Viruses,Murine Leukemia Virus,Murine Leukemia Viruses,Graffi Chloroleukemic Strain,Graffis Chloroleukemic Strain,Leukemia Viruses, Mouse
D009894 Opportunistic Infections An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression. Infection, Opportunistic,Infections, Opportunistic,Opportunistic Infection
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D002708 Chlorella Nonmotile unicellular green algae potentially valuable as a source of high-grade protein and B-complex vitamins. Chlorellas
D005260 Female Females

Related Publications

T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Abrogation of resistance to severe mousepox in C57BL/6 mice infected with LP-BM5 murine leukemia viruses.
February 1987, Journal of virology,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Modification of lymphoid subsets by chronic ethanol consumption in C57Bl/6 mice infected with LP-BM5 murine leukemia virus.
July 1992, Alcohol and alcoholism (Oxford, Oxfordshire),
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Opportunistic infections and retrovirus-induced immunodeficiency: studies of acute and chronic infections with Toxoplasma gondii in mice infected with LP-BM5 murine leukemia viruses.
October 1992, Infection and immunity,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS.
March 1999, Journal of neuroimmunology,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
LP-BM5 infection impairs spatial working memory in C57BL/6 mice in the Morris water maze.
February 2000, Brain research,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Protective effects of Chlorella vulgaris in lead-exposed mice infected with Listeria monocytogenes.
June 2003, International immunopharmacology,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice.
January 2011, Bioscience, biotechnology, and biochemistry,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Effects of Chlorella vulgaris extract on cytokines production in Listeria monocytogenes infected mice.
August 2002, Immunopharmacology and immunotoxicology,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses.
August 1999, Journal of virology,
T Hasegawa, and M Okuda, and M Makino, and K Hiromatsu, and K Nomoto, and Y Yoshikai
Evidence of neuronal degeneration in C57B1/6 mice infected with the LP-BM5 leukemia retrovirus mixture.
January 1998, Molecular and chemical neuropathology,
Copied contents to your clipboard!