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Human antibody response to Toscana virus glycoproteins expressed by recombinant baculovirus. 2002
Paola Di Bonito, and
Simona Bosco, and
Stefania Mochi, and
Luisa Accardi, and
Maria G Ciufolini, and
Loredana Nicoletti, and
Colomba Giorgi
Laboratory of Virology, Istituto Superiore di Sanità , Rome, Italy.
The arthropod-borne Toscana virus has been associated with acute neurological disease in humans. In this study, the viral envelope glycoproteins were expressed in soluble form in a baculovirus system. The recombinant sGN and sGC proteins were used as viral antigens in a Western blot assay to analyze the specific immune response in sera from patients with recognized virus-associated aseptic meningitis. The anti-glycoprotein and the anti-nucleoprotein N IgG responses were compared by an immunoassay based on the recombinant proteins. In this system, all the sera showed a high reactivity to the N protein, but they differed in the response to the glycoproteins.
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