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Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones. 2002
Veerachamy Alagarsamy, and
Viswas Raja Salomon, and
Gnanavel Vanikavitha, and
Veeran Paluchamy, and
Muniyandi Ravi Chandran, and
Augustin Arnald Sujin, and
Arunachalam Thangathiruppathy, and
Sivaperuman Amuthalakshmi, and
Rajappan Revathi
Medicinal Chemistry Laboratory, SB College of Pharmacy, Sivakasi, India. samy_veera@yahoo.com
A series of novel 2-phenyl-3-substituted quinazolin-4(3H)-ones have been synthesized by treating methyl-N-(2-phenyl quinazolin-3-yl-4(3H)-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds A1, A2 and A3 shown more potent analgesic activity, and the compound A3 shown more potent anti-inflammatory activity than the reference standard diclofenac sodium.
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