BIOMAT Database Logo BIOMAT Database Logo

Synthesis of 3-(2-pyridyl)-2-substituted-quinazolin-4(3H)-ones as new analgesic and anti-inflammatory agents. 2008

V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Medicinal Chemistry R&D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankovil, Tamil Nadu-626 190, India. drvalagarsamy@gmail.com

A new series of 3-(2-pyridyl)-2-substituted-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 2-hydrazino-3-(2-pyridyl)-quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(2-pyridyl)-quinazolin-4(3H)-one was synthesized from 2-aminopyridine. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. While the test compounds exhibited significant activity, compound 2-(1-ethylpropylidene)-hydrazino-3-(2-pyridyl)-quinazolin-4(3H)-one (AS2) showed moderate analgesic activity and compound 2-(1-methylbutylidene)-hydrazino-3-(2-pyridyl)-quinazolin-4(3H)-one (AS3) showed realistic anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic side effect when compared to aspirin.

UI MeSH Term Description Entries
D007202 Indicators and Reagents Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499) Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D008297 Male Males
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D011725 Pyridines Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D012015 Reference Standards A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy. Standard Preparations,Standards, Reference,Preparations, Standard,Standardization,Standards,Preparation, Standard,Reference Standard,Standard Preparation,Standard, Reference
D002351 Carrageenan A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES. Carrageenin,iota-Carrageenan,kappa-Carrageenan,lambda-Carrageenan,iota Carrageenan,kappa Carrageenan,lambda Carrageenan
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D005260 Female Females
D000700 Analgesics Compounds capable of relieving pain without the loss of CONSCIOUSNESS. Analgesic,Anodynes,Antinociceptive Agents,Analgesic Agents,Analgesic Drugs,Agents, Analgesic,Agents, Antinociceptive,Drugs, Analgesic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
February 2010, Archiv der Pharmazie,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
January 2007, Archiv der Pharmazie,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
May 2007, The Journal of pharmacy and pharmacology,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones.
May 2004, Biological & pharmaceutical bulletin,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-butyl-3-substituted quinazolin-4-(3H)-ones.
June 2005, Biological & pharmaceutical bulletin,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
December 2003, Biological & pharmaceutical bulletin,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones.
November 2002, Biological & pharmaceutical bulletin,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis and pharmacological evaluation of some 3-(4-methoxyphenyl)-2-substitutedamino-quinazolin-4(3H)-ones as analgesic and anti-inflammatory agents.
January 2007, Chemical & pharmaceutical bulletin,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis and antibacterial activity of some new 2-aryloxymethyl-3-substituted-quinazolin-4(3H)-ones.
December 1988, Die Pharmazie,
V Alagarsamy, and V Raja Solomon, and M Murugan, and R Sankaranarayanan, and P Periyasamy, and R Deepa, and T Durai Anandkumar
Synthesis of 6-substituted 2-phenyl-3-(5-substituted mercapto-1,3,4, thiadiazol-2-yl)quinazolin-4-(3H)-ones as antitubercular agents.
September 1983, Archiv der Pharmazie,
Copied contents to your clipboard!