-transparent.png){kind=logo}
The synthesis of a new series of phenylacetylguanidines is described. Several of them exhibited high antihypertensive activity in the rat. The most potent member of the series is N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride [2,6-dichlorophenylacetylguanidine hydrochloride, compound 19], which is now in clinical study under the clinical code number BS 100-141. The structure-activity relationships in this class of compounds are discussed.
Related Publications
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
June 1961,
Science (New York, N.Y.),
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
February 1973,
Journal of medicinal chemistry,
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
January 1988,
Fundamental & clinical pharmacology,
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
April 1996,
Deutsche medizinische Wochenschrift (1946),
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
January 1984,
Farmakologiia i toksikologiia,
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
February 1996,
American family physician,
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
April 1971,
Journal of medicinal chemistry,
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
January 2010,
American journal of therapeutics,
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
July 1961,
Journal of medicinal and pharmaceutical chemistry,
J B Bream, and
H Lauener, and
C W Picard, and
G Scholtysik, and
T G White
August 1981,
Journal of medicinal chemistry,
