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The ampicillin concentrations in serum, urine, kidney, urinary bladder, prostate gland, testis, muscle and skin from 64 urological patients with normal renal function were determined with the agar diffusion method after oral doses of 700 mg of the pivaloyloxymethyl ester of ampicillin (pivampicillin, Pondocillin). The tissue samples were obtained at urological operations, prostatectomy, nephrectomy and orchiectomy. The serum concentration was highest between 2 and 4 h and the urine concentration between 4 and 6 h after intake. The serum concentration was considerably lower than reported in literature, which was shown to 0e due either to the effect of preoperative medication or anesthesia, or to both.
O Alfthan, and
O V Renkonen
February 1975,
MMW, Munchener medizinische Wochenschrift,
O Alfthan, and
O V Renkonen
December 1975,
European journal of clinical pharmacology,
O Alfthan, and
O V Renkonen
June 1974,
Arzneimittel-Forschung,
O Alfthan, and
O V Renkonen
January 1972,
Acta tuberculosea et pneumologica Belgica,
O Alfthan, and
O V Renkonen
January 1990,
Infection,
O Alfthan, and
O V Renkonen
March 1979,
The Journal of antimicrobial chemotherapy,
O Alfthan, and
O V Renkonen
January 1974,
European journal of clinical pharmacology,
O Alfthan, and
O V Renkonen
May 1975,
Casopis lekaru ceskych,
O Alfthan, and
O V Renkonen
July 1974,
Clinical pharmacology and therapeutics,
O Alfthan, and
O V Renkonen
September 1973,
The New Zealand medical journal,
