-transparent.png){kind=logo}
The present report describes clinical, hematological and biochemical studies of a 27-year old Egyptian woman in whom a fast moving Hb variant was found. The abnormal Hb constituted 48% of the total erythrocyte Hb of the propositus and her father. Structural studies demonstrated that in the abnormal Hb lysine beta 65 is replaced by glutamine. The new Hb mutant is designated hemoglobin J Cairo beta 65 (E9) Lys leads to Gln. This substitution results in only a moderate decrease in cooperativity. No evidence of Hb instability was found. A slight anemic state has been observed in the propositus since she reached adolescence.
Related Publications
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
January 1981,
Hemoglobin,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
January 1978,
Hemoglobin,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
February 1974,
FEBS letters,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
December 1977,
FEBS letters,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
January 1983,
Hemoglobin,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
January 1975,
Nouvelle revue francaise d'hematologie,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
January 1982,
Hemoglobin,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
January 1981,
Hemoglobin,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
April 1980,
Biochimica et biophysica acta,
M C Garel, and
W Hassan, and
M T Coquelet, and
M Goossens, and
J Rosa, and
N Arous
January 1990,
Hemoglobin,
