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We report a new case of hemoglobin J. Broussais, present in its heterozygote form in a seven year old child from Martinque. The structural characteristics of this abnormal hemoglobin have been compared by three methods: 1. By analytical and preparative finger-printing on silica gel thin layer plates after tryptic digestion. 2. By a programmed separation of tryptic peptides on various ion exchange resins. 3. And by automatic sequencing of the peptides obtained following CNBr cleavage and separation by gel filtration chromatography. The functional behaviour of this hemoglobin was not modified by the substitution of an Asn for a Lys residue at position 90, although its presence induced slight hematological disorders in the patient. Abnormal hemoglobins which have been identified in Martinique and Guadeloupe are reviewed.
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M Cohen-Solal, and
N Schlegel, and
Y Blouquit, and
J Thillet, and
J C de Linval, and
J Rosa
August 1970,
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F Braconnier, and
M Cohen-Solal, and
N Schlegel, and
Y Blouquit, and
J Thillet, and
J C de Linval, and
J Rosa
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F Braconnier, and
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J Rosa
January 1976,
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F Braconnier, and
M Cohen-Solal, and
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Zhonghua yi xue za zhi,
F Braconnier, and
M Cohen-Solal, and
N Schlegel, and
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J C de Linval, and
J Rosa
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F Braconnier, and
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F Braconnier, and
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J C de Linval, and
J Rosa
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Pathology,
F Braconnier, and
M Cohen-Solal, and
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Y Blouquit, and
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J C de Linval, and
J Rosa
January 1983,
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F Braconnier, and
M Cohen-Solal, and
N Schlegel, and
Y Blouquit, and
J Thillet, and
J C de Linval, and
J Rosa
August 1982,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
