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Synthesis of 1-beta-D-ribofuranosyltetrazole and two 5-substituted derivatives, i.e., the 5-carboxamide and 5-acetamide, is described. The stereochemical structure of the parent tetrazole ribonucleoside has been established by means of nuclear Overhauser effect and x-ray crystallography. By analogy to the parent compound, the two 5-substituted tetrazole nucleosides are also assigned the beta configuration on the basis of the NMR coupling constant of the anomeric proton and the site of N-ribosylation is determined by 13C NMR studies. Results are also presented on antiviral testing of these synthetic tetrazole nucleosides against influenza A2/Asian/J-305 virus infection in mice.
M S Poonian, and
E F Nowoswiat, and
J F Blount, and
T H Williams, and
R G Pitcher, and
M J Kramer
January 2002,
Nucleosides, nucleotides & nucleic acids,
M S Poonian, and
E F Nowoswiat, and
J F Blount, and
T H Williams, and
R G Pitcher, and
M J Kramer
March 1978,
Biochimica et biophysica acta,
M S Poonian, and
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J F Blount, and
T H Williams, and
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M J Kramer
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M S Poonian, and
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M J Kramer
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M S Poonian, and
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M J Kramer
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M S Poonian, and
E F Nowoswiat, and
J F Blount, and
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M J Kramer
February 2019,
European journal of medicinal chemistry,
M S Poonian, and
E F Nowoswiat, and
J F Blount, and
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M J Kramer
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M S Poonian, and
E F Nowoswiat, and
J F Blount, and
T H Williams, and
R G Pitcher, and
M J Kramer
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Carbohydrate research,
M S Poonian, and
E F Nowoswiat, and
J F Blount, and
T H Williams, and
R G Pitcher, and
M J Kramer
June 2023,
Archiv der Pharmazie,
M S Poonian, and
E F Nowoswiat, and
J F Blount, and
T H Williams, and
R G Pitcher, and
M J Kramer
May 2017,
Archiv der Pharmazie,
