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Antiviral agents: synthesis of furylpyrimidinones and evaluation of their cytostatic and antiviral activity. 1991
M Botta, and
F De Angelis, and
F Corelli, and
M Menichincheri, and
R Nicoletti, and
M E Marongiu, and
A Pani, and
P La Colla
Dipartimento Farmaco Chimico Tecnologico, Università di Siena.
Condensation between furyllithium reagents and pyrimidinones 1, 2, 3, and 4 has been studied. The product composition is strongly dependent upon the reaction conditions and purification methodologies. Cytostatic and antiviral activities of some substrates and reaction products is reported.
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