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[Effect and mechanism of securinine on synaptic transmission in the dentate gyrus of anesthetized rats]. 2001

L Xu, and J T Zhang
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

OBJECTIVE To study the effects of (+) and (-) securinine on the basic synaptic transmission and long-term potentiation (LTP) induced by high-frequency stimulation in the dentate gyrus of anesthetized rats and its possible mechanism. METHODS The population spike (PS) was recorded by electrophysiological techniques. RESULTS The results showed that at the concentration of 2 x 10(-9) mol.L-1, (+), (-) securinine showed no effect on either the basal PS or LTP. At high cocentrations (2 x 10(-8), 2 x 10(-7) mol.L-1), (+), (-) securinine not only potentiated the basal PS but also enhanced the magnitude of LTP. (+), (-) Securinine showed similar effects; and the effects were completely inhibited by the inhibitory amino acid GABA. CONCLUSIONS These results suggest that the effects of (+), (-) securinine on induction and maintenance of LTP may be related to its blockade of GABA receptor.

UI MeSH Term Description Entries
D007783 Lactones Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES. Lactone
D008297 Male Males
D009435 Synaptic Transmission The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES. Neural Transmission,Neurotransmission,Transmission, Neural,Transmission, Synaptic
D010880 Piperidines A family of hexahydropyridines.
D006572 Heterocyclic Compounds, Bridged-Ring A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms. Bridged-Ring Heterocyclic Compounds,Bridged Ring Heterocyclic Compounds,Compounds, Bridged-Ring Heterocyclic,Heterocyclic Compounds, Bridged Ring
D006576 Heterocyclic Compounds, 4 or More Rings A class of heterocyclic compounds that include four or more fused rings. Both aromatic or non-aromatic ring structures are included in this category. Heterocyclic Compounds with 4 or More Rings,Five Ring Heterocyclic Compounds,Four Ring Heterocyclic Compounds,Fused Heterocyclic Compounds, Five-Ring,Fused Heterocyclic Compounds, Four-Ring,Heterocyclic Compounds with Four or More Rings,Heterocyclic Compounds, 4-Ring,Heterocyclic Compounds, 5-Ring,Heterocyclic Cpds, 4 Ring,Heterocyclic Cpds, 4 or More Rings,Heterocyclic Cpds, 5 Ring,4-Ring Heterocyclic Compounds,5-Ring Heterocyclic Compounds,Fused Heterocyclic Compounds, Five Ring,Fused Heterocyclic Compounds, Four Ring,Heterocyclic Compounds, 4 Ring,Heterocyclic Compounds, 5 Ring
D000470 Alkaloids Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed) Alkaloid,Plant Alkaloid,Plant Alkaloids,Alkaloid, Plant,Alkaloids, Plant
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001381 Azepines Seven membered heterocyclic rings containing a NITROGEN atom. Hexamethyleneimines
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer

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