-transparent.png){kind=logo}
A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. 2003
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan.
In this study we have cloned a novel member of mouse protein phosphatase 2C family, PP2Czeta, which is composed of 507 amino acids and has a unique N-terminal region. The overall similarity of the amino acid sequence between PP2Czeta and PP2Calpha was 22%. On Northern blot analysis PP2Czeta was found to be expressed specifically in the testicular germ cells. PP2Czeta expressed in COS7 cells was able to associate with ubiquitin conjugating enzyme 9 (UBC9) and the association was enhanced by co-expression of small ubiquitin-related modifier-1 (SUMO-1), suggesting that PP2Czeta exhibits its specific role through its SUMO-induced recruitment to UBC9.
Related Publications
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
June 2006,
International journal of molecular medicine,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
October 1997,
Gene,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
November 2003,
Biochimica et biophysica acta,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
April 2022,
Breast cancer research and treatment,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
April 2013,
BMC cancer,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
May 1998,
Proceedings of the National Academy of Sciences of the United States of America,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
June 2012,
Archives of Iranian medicine,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
June 1997,
The Journal of biological chemistry,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
September 1992,
Biochimica et biophysica acta,
Mitsuhiro Kashiwaba, and
Koji Katsura, and
Motoko Ohnishi, and
Mutsuo Sasaki, and
Hiromitsu Tanaka, and
Yoshitake Nishimune, and
Takayasu Kobayashi, and
Shinri Tamura
November 2004,
Molecular and cellular biology,
