BIOMAT Database Logo BIOMAT Database Logo

Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. 2003

Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Ceta. Sequence analysis suggests that PP2Ceta, PP2Czeta and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Ceta had extremely low activity against alpha-casein compared with PP2Calpha and was localized mainly in cell nuclei, suggesting that PP2Ceta dephosphorylates a unique nuclear protein(s) in the cells.

UI MeSH Term Description Entries
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D010749 Phosphoprotein Phosphatases A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992) Phosphoprotein Phosphatase,Phosphoprotein Phosphohydrolase,Protein Phosphatase,Protein Phosphatases,Casein Phosphatase,Ecto-Phosphoprotein Phosphatase,Nuclear Protein Phosphatase,Phosphohistone Phosphatase,Phosphoprotein Phosphatase-2C,Phosphoseryl-Protein Phosphatase,Protein Phosphatase C,Protein Phosphatase C-I,Protein Phosphatase C-II,Protein Phosphatase H-II,Protein-Serine-Threonine Phosphatase,Protein-Threonine Phosphatase,Serine-Threonine Phosphatase,Threonine Phosphatase,Ecto Phosphoprotein Phosphatase,Phosphatase C, Protein,Phosphatase C-I, Protein,Phosphatase C-II, Protein,Phosphatase H-II, Protein,Phosphatase, Casein,Phosphatase, Ecto-Phosphoprotein,Phosphatase, Nuclear Protein,Phosphatase, Phosphohistone,Phosphatase, Phosphoprotein,Phosphatase, Phosphoseryl-Protein,Phosphatase, Protein,Phosphatase, Protein-Serine-Threonine,Phosphatase, Protein-Threonine,Phosphatase, Serine-Threonine,Phosphatase, Threonine,Phosphatase-2C, Phosphoprotein,Phosphatases, Phosphoprotein,Phosphatases, Protein,Phosphohydrolase, Phosphoprotein,Phosphoprotein Phosphatase 2C,Phosphoseryl Protein Phosphatase,Protein Phosphatase C I,Protein Phosphatase C II,Protein Phosphatase H II,Protein Phosphatase, Nuclear,Protein Serine Threonine Phosphatase,Protein Threonine Phosphatase,Serine Threonine Phosphatase
D003001 Cloning, Molecular The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells. Molecular Cloning
D000071636 Protein Phosphatase 2C One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5. Magnesium-Dependent Protein Phosphatase 2C beta,PP2C beta,PP2Cepsilon,PP2Cgamma,PPM1 Magnesium-Dependent Protein Phosphatases,PPM1 Protein Phosphatases,PPM1D Phosphatase,PPM1E Phosphatase,PPM1G Phosphatase,Ppm1b Phosphatase,Protein Phosphatase 1D Magnesium-Dependent, delta isoform,Protein Phosphatase 2C beta,Protein Phosphatase 2C delta,Protein Phosphatase 2C epsilon,Protein Phosphatase 2C gamma,Ptc2 Phosphatase,2C, Protein Phosphatase,Magnesium Dependent Protein Phosphatase 2C beta,PPM1 Magnesium Dependent Protein Phosphatases,Phosphatase 2C, Protein,Phosphatase, PPM1D,Phosphatase, PPM1E,Phosphatase, PPM1G,Phosphatase, Ppm1b,Phosphatase, Ptc2,Phosphatases, PPM1 Protein,Protein Phosphatase 1D Magnesium Dependent, delta isoform,Protein Phosphatases, PPM1,beta, PP2C
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D020224 Expressed Sequence Tags Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived. ESTs,Expressed Sequence Tag,Sequence Tag, Expressed,Sequence Tags, Expressed,Tag, Expressed Sequence,Tags, Expressed Sequence

Related Publications

Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa.
June 2006, International journal of molecular medicine,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family.
October 1997, Gene,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Molecular cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon*).
September 2004, Molecular biology reports,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Molecular cloning and primary structure of a protein phosphatase 2C isoform.
February 1992, FEBS letters,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Molecular cloning of rat type 2C (IA) protein phosphatase mRNA.
March 1989, Proceedings of the National Academy of Sciences of the United States of America,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9.
March 2003, FEBS letters,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Molecular cloning of protein phosphatase type 2C isoforms from retinal cDNA.
January 1998, Methods in molecular biology (Clifton, N.J.),
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.
July 2001, Molecular and cellular biology,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein family.
June 2005, DNA sequence : the journal of DNA sequencing and mapping,
Ken-ichiro Komaki, and Koji Katsura, and Motoko Ohnishi, and Ming Guang Li, and Masato Sasaki, and Makoto Watanabe, and Takayasu Kobayashi, and Shinri Tamura
Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases.
April 1994, FEBS letters,
Copied contents to your clipboard!