-transparent.png){kind=logo}
Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir. 2003
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
We synthesized bicyclic ether sialidase inhibitors such as tetrahydro-furan-2-yl, tetrahydro-pyran-2-yl, and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3' and C-4' positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound 11a in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate.
Related Publications
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
August 2002,
Bioorganic & medicinal chemistry letters,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
September 2009,
Carbohydrate research,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
February 1999,
Bioorganic & medicinal chemistry letters,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
June 2018,
European journal of medicinal chemistry,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
August 2014,
Bioorganic & medicinal chemistry,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
May 2024,
Bioorganic & medicinal chemistry,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
January 1983,
Arzneimittel-Forschung,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
January 1999,
Methods in molecular medicine,
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
May 2022,
Molecules (Basel, Switzerland),
Takeshi Masuda, and
Satoshi Shibuya, and
Masami Arai, and
Shuku Yoshida, and
Takanori Tomozawa, and
Akiko Ohno, and
Makoto Yamashita, and
Takeshi Honda
October 1990,
Antimicrobial agents and chemotherapy,
