Biomaterial Database

Vocalization after periaqueductal grey inactivation with the GABA agonist muscimol in the squirrel monkey. 2003

S Siebert, and U Jürgens

German Primate Centre, Kellnerweg 4, 37077 Göttingen, Germany.

In order to specify the role of the periaqueductal grey (PAG) in vocal production, we tested the effect of PAG inactivation on the electrical elicitability of vocalization from various brain structures in the squirrel monkey. For this purpose, we implanted stimulation electrodes at 64 vocalization-eliciting sites throughout the brain and compared the elicitability of vocalization before and after muscimol injection into the PAG. It turned out that only vocalization sites in the forebrain (cingulate cortex, hypothalamus) and rostralmost mesencephalic reticular formation could be blocked by PAG inactivation, whereas all vocalization sites in the caudal midbrain, pons and medulla remained unaffected. It is concluded that the PAG is not the site of vocal pattern generation, but rather serves gating functions.

UI	MeSH Term	Description	Entries
D009118	Muscimol	A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.	Agarin,Pantherine
D010487	Periaqueductal Gray	Central gray matter surrounding the CEREBRAL AQUEDUCT in the MESENCEPHALON. Physiologically it is probably involved in RAGE reactions, the LORDOSIS REFLEX; FEEDING responses, bladder tonus, and pain.	Mesencephalic Central Gray,Midbrain Central Gray,Central Gray Substance of Midbrain,Central Periaqueductal Gray,Griseum Centrale,Griseum Centrale Mesencephali,Periaqueductal Gray Matter,Substantia Grisea Centralis,Substantia Grisea Centralis Mesencephali,Central Gray, Mesencephalic,Central Gray, Midbrain,Gray Matter, Periaqueductal,Gray, Central Periaqueductal,Griseum Centrale Mesencephalus,Periaqueductal Grays, Central
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012453	Saimiri	A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.	Monkey, Squirrel,Squirrel Monkey,Monkeys, Squirrel,Saimirus,Squirrel Monkeys
D014828	Vocalization, Animal	Sounds used in animal communication.	Singing, Animal,Sound Communication, Animal,Vocal Communication, Animal,Animal Singing,Animal Singings,Animal Sound Communication,Animal Sound Communications,Animal Vocal Communication,Animal Vocal Communications,Animal Vocalization,Animal Vocalizations,Communication, Animal Sound,Communication, Animal Vocal,Communications, Animal Sound,Communications, Animal Vocal,Singings, Animal,Sound Communications, Animal,Vocal Communications, Animal,Vocalizations, Animal
D018755	GABA Agonists	Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).	gamma-Aminobutyric Acid Agonists,GABA Agonist,GABA Receptor Agonist,GABA Receptor Agonists,gamma-Aminobutyric Acid Agonist,Acid Agonist, gamma-Aminobutyric,Acid Agonists, gamma-Aminobutyric,Agonist, GABA,Agonist, GABA Receptor,Agonist, gamma-Aminobutyric Acid,Agonists, GABA,Agonists, GABA Receptor,Agonists, gamma-Aminobutyric Acid,Receptor Agonist, GABA,Receptor Agonists, GABA,gamma Aminobutyric Acid Agonist,gamma Aminobutyric Acid Agonists