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A radioimmunoassay is described for the measurement of dehydroepiandrosterone sulphate in serum. The method requires 0.1 ml of serum that needs no purification other than a single ether extraction. It is both rapid and economical, procedural losses are small and precision and accuracy are acceptable for both normal and pathological sera. Normal values have been established for children and adults which show a relationship to chronological age, values rising steadily as puberty intevenes, peak values occurring between 20 and 27 years, with a decline thereafter. An empirical curve was fitted to the data and approximate normal limits were obtained. The mean value for pregnanat women in the age range 20-40 years, was statistically significantly lower than in non-pregnant, premenopausal women. The levels of dehydroepiandrosterone sulphate in cord and newborn blood, were higher than at any other time during childhood until signs of puberty were demonstrable. Elevated levels are reported in six patients with untreated congenital adrenal hyperplasia and in one patient with a tumour of the adrenal cortex. It is suggested that this assay provides a useful and precise index of adrenal androgen secretion.
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
April 1974,
Endocrinologia japonica,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
March 1985,
Journal of steroid biochemistry,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
December 1972,
Steroids,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
September 1975,
Clinical endocrinology,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
August 1975,
British journal of obstetrics and gynaecology,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
January 1988,
The British veterinary journal,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
June 1977,
Acta endocrinologica,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
January 1957,
The Journal of clinical investigation,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
September 1986,
Journal of steroid biochemistry,
M R Smith, and
B T Rudd, and
A Shirley, and
P H Rayner, and
J W Williams, and
N M Duignan, and
P V Bertrand
December 1988,
Maturitas,
