-transparent.png){kind=logo}
Four selected adults with different patterns of osteodystrophy receiving regular dialysis were treated with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) 0-5-2 mug/day for 10 to 12 months. In two patients, one with osteitis fibrosa and the other with osteomalacia, significant biochemical, radiological, and histological improvements occurred, and total body calcium measured by in-vivo neutron activation analysis increased. In two patients, in whom there were no increases of whole-body calcium, neither biochemical improvement nor healing of bone lesions occurred during the study; in one of these patients the effect of 1-alpha-OHD3 on bone resorption may have contributed to loss of body calcium and deterioration of bone disease. 1-alpha-OHD3 may therefore be a valuable adjunct in the treatment of only some patients with renal osteodystrophy. Whole-body in-vivo neutron activation seems to provide a sensitive and non-invasive index of early response to treatment.
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
December 1974,
Journal d'urologie et de nephrologie,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
May 1977,
Calcified tissue research,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
October 1977,
British medical journal,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
September 1977,
British medical journal,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
February 1987,
Transplantation proceedings,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
January 1976,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
April 1978,
Ugeskrift for laeger,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
November 1970,
Archives of internal medicine,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
February 1979,
Kidney international,
R B Naik, and
P Gosling, and
C P Price, and
B H Robinson, and
J T Dabek, and
D A Heath, and
H M James, and
J A Kanis, and
R Smith
April 1976,
Clinical nephrology,
