-transparent.png){kind=logo}
A 34-year-old female with cyclic neutropenia is reported. Family studies showed that her three sons and her mother were also involved. Oscillations in the blood neutrophil counts were almost regular, with a periodicity of 21 days. Numbers of colony-forming unit--granulocyte macrophage (CFU-GM) formed from the bone marrow cells of normal volunteers co-cultured with the patient's serum or mononuclear cell-conditioned medium (MNC-CM) were examined. Her serum prepared during the neutropenic phase inhibited the growth of CFU-GM, while her MNC-CM stimulated it. Human granulocyte colony-stimulating factor (hG-CSF) level in her serum was persistently high, with the peak occurring during the neutropenic phase. These results suggest that some inhibitory factors in the serum may be pathophysiologically important for cyclic neutropenia. To control infections, a pharmacological dose of hG-CSF was administered for 7 days around the early neutropenic phase. Her peripheral neutrophil counts oscillated from 1,200/mm3 to 17,000/mm3 with G-CSF, and from 150/mm3 to 1,800/mm3 without G-CSF.
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
April 2020,
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
January 1998,
Ryoikibetsu shokogun shirizu,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
October 1991,
Orvosi hetilap,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
January 2016,
International journal of applied & basic medical research,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
April 1988,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
October 2017,
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
June 1983,
Pediatric dentistry,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
January 1985,
ASDC journal of dentistry for children,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
April 1957,
Wisconsin medical journal,
T Inoue, and
K Tani, and
M Tajiri, and
Y Ishida, and
M Seguchi, and
H Tanaka, and
S Asano, and
T Kaneko, and
N Matsumoto
September 1953,
Journal of the American Medical Association,
