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This rare disorder characterized by regular periodic oscillations in the number of peripheral neutrophils from normal to neutropenic levels. A case of a fourteen years old boy is presented who developed the disease at age of four years. Neutropenic periods appeared at intervals of 21 days and were associated with recurrent infections--gingivitis, stomatitis, conjunctivitis. The possible mechanism of impaired granulopoiesis and different therapeutic approaches are discussed.
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