The influence of adaptation to periodic pressure-chamber hypoxia produced on the condition of the lipid spectrum of blood serum before and after adaptation as well as in 3, 6 and 10 months after hypoxic training was studied in 46 patients with ischemic heart disease working at a enterprise specializing in winning and processing the hydrogen-sulfide-containing gas-condensate. The adaptation therapy was found to result in a reliable reduction of the total cholesterol level, of the level of cholesterol of lipoproteins of the low and extra low densities and of triglycerides; it also contributed to the increase of cholesterol of lipoproteins of the high density in blood serum, which, in the end, ensures a reduced atherogenic coefficient. The positive-for-organism changes in the lipid spectrum of blood serum hold on in patients with coronary heart disease for as long as 6 months after the adaptation therapy. The nature and degree of blood lipids' changes depend on an initial level of the atherogenic index; they were maximally pronounced in persons with the index exceeding 3, and virtually absent in IHD patients with the atherogenicity coefficient being below the mentioned figure.