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Two cases with trisomy 16 confined to the placenta are presented. Prenatal diagnosis was indicated because of fetal growth retardation. In case 1, a phenotypically normal but small-for-date boy was born. In case 2, the fetus turned out to be triploid on cordocentesis. In both instances the trisomy 16 was recovered from the placenta. Recovery indicates that the abnormality was present in the placenta during the time of fetal growth retardation, which supports an aetiological relationship. Strict appliance of the current models cannot readily explain the observed discrepancies. In case 2, a chimeric placenta as a result of a vanishing twin is assumed. Cases of placental trisomy 16 published after 1988 are reviewed. It is concluded that confined placental trisomy 16 can cause intrauterine growth retardation if present in both the direct preparation and the villus culture. The chances of finding a chromosomally abnormal fetus (mosaic trisomy 16, triploidy) after diagnosis of trisomy 16 in chorionic villi are low but warrant further investigations.
J G Post, and
J G Nijhuis
August 1996,
Prenatal diagnosis,
J G Post, and
J G Nijhuis
May 1996,
American journal of obstetrics and gynecology,
J G Post, and
J G Nijhuis
August 1997,
Prenatal diagnosis,
J G Post, and
J G Nijhuis
November 1988,
American journal of medical genetics,
J G Post, and
J G Nijhuis
December 2018,
Prenatal diagnosis,
J G Post, and
J G Nijhuis
August 1990,
Prenatal diagnosis,
J G Post, and
J G Nijhuis
November 2018,
Prenatal diagnosis,
J G Post, and
J G Nijhuis
October 1989,
Lancet (London, England),
J G Post, and
J G Nijhuis
July 2009,
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC,
J G Post, and
J G Nijhuis
December 2000,
Clinical genetics,
