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Discovery of a novel route to 2'-deoxy and 2'-functional pyrimidine nucleosides via 3',5'-O-sulfinyl xylo-nucleosides. 2002

Ken-ichi Takatsuki, and Shigeo Kohmoto, and Keiki Kishikawa, and Haruhiro Yamashita, and Makoto Yamamoto
Ichikawa Research Institute, Kobayashi Perfumery CO., LTD., 4-12-1 Ohwada, Ichikawa-City 272-0025, Japan.

We synthesized 2,2'-anhydro-pyrimidine nucleosides through a novel and efficient rearrangement with 3',5'-O-sulfinyl xylo nucleosides which were prepared from an inexpensive starting material, D-xylose. A variety of 2'-deoxy and 2'-functional pyrimidine nucleosides can be prepared from 2,2'-anhydro-pyrimidine nucleosides.

UI MeSH Term Description Entries
D011741 Pyrimidine Nucleosides Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES. Nucleosides, Pyrimidine

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