-transparent.png){kind=logo}
We studied the antiviral activity of nuclease-resistant alpha-anomeric oligonucleotides. An alpha-oligonucleotide (20-mer) targeted to the primer binding site (PBS) of murine retroviruses inhibited viral spreading. The inhibition only occurred when the cells had been electropermeabilized in the presence of the oligonucleotide. The PBS sequence is involved in reverse transcription and in translation. The data suggest that the oligonucleotide could perturb reverse transcription activity. Thus, either the oligonucleotide induced a decrease in initiation or it inhibited the extension of the minus or plus strands DNA during reverse transcription. These results show that reverse transcription may be an interesting target for antisense oligonucleotides.
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
June 1989,
Biochemical and biophysical research communications,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
September 1994,
Antiviral research,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
May 2009,
Bioorganic & medicinal chemistry letters,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
February 2021,
RSC chemical biology,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
March 2015,
Chemical communications (Cambridge, England),
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
February 2011,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
January 1978,
Proceedings of the National Academy of Sciences of the United States of America,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
April 2021,
Nanoscale,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
January 1976,
Annals of the New York Academy of Sciences,
M Lavignon, and
N Tounekti, and
B Rayner, and
J L Imbach, and
G Keith, and
J Paoletti, and
C Malvy
February 2010,
Zhongguo shi yan xue ye xue za zhi,
