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Gene expression patterns in ovarian carcinomas. 2003
Marci E Schaner, and
Douglas T Ross, and
Giuseppe Ciaravino, and
Therese Sorlie, and
Olga Troyanskaya, and
Maximilian Diehn, and
Yan C Wang, and
George E Duran, and
Thomas L Sikic, and
Sandra Caldeira, and
Hanne Skomedal, and
I-Ping Tu, and
Tina Hernandez-Boussard, and
Steven W Johnson, and
Peter J O'Dwyer, and
Michael J Fero, and
Gunnar B Kristensen, and
Anne-Lise Borresen-Dale, and
Trevor Hastie, and
Robert Tibshirani, and
Matt van de Rijn, and
Nelson N Teng, and
Teri A Longacre, and
David Botstein, and
Patrick O Brown, and
Branimir I Sikic
Stanford University School of Medicine, Stanford, California 94305-5151, USA.
We used DNA microarrays to characterize the global gene expression patterns in surface epithelial cancers of the ovary. We identified groups of genes that distinguished the clear cell subtype from other ovarian carcinomas, grade I and II from grade III serous papillary carcinomas, and ovarian from breast carcinomas. Six clear cell carcinomas were distinguished from 36 other ovarian carcinomas (predominantly serous papillary) based on their gene expression patterns. The differences may yield insights into the worse prognosis and therapeutic resistance associated with clear cell carcinomas. A comparison of the gene expression patterns in the ovarian cancers to published data of gene expression in breast cancers revealed a large number of differentially expressed genes. We identified a group of 62 genes that correctly classified all 125 breast and ovarian cancer specimens. Among the best discriminators more highly expressed in the ovarian carcinomas were PAX8 (paired box gene 8), mesothelin, and ephrin-B1 (EFNB1). Although estrogen receptor was expressed in both the ovarian and breast cancers, genes that are coregulated with the estrogen receptor in breast cancers, including GATA-3, LIV-1, and X-box binding protein 1, did not show a similar pattern of coexpression in the ovarian cancers.
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