-transparent.png){kind=logo}
Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. The multigene family of G protein alpha subunits, which interact with receptors and effectors, exhibit a high level of sequence diversity. In mammals, 15 G alpha subunit genes can be grouped by sequence and functional similarities into four classes. We have determined the murine chromosomal locations of all 15 G alpha subunit genes using an interspecific backcross derived from crosses of C57BL/6J and Mus spretus mice. These data, in combination with mapping studies in humans, have provided insight into the events responsible for generating the genetic diversity found in the mammalian alpha subunit genes and a framework for elucidating the role of the G alpha subunits in disease.
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
January 1994,
Society of General Physiologists series,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
December 1996,
Genome research,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
January 2007,
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
October 1996,
Journal of molecular evolution,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
October 2010,
Molecular biology and evolution,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
March 1991,
Proceedings of the National Academy of Sciences of the United States of America,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
February 1995,
Biochemical Society transactions,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
October 1995,
Journal of molecular and cellular cardiology,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
January 1991,
Advances in experimental medicine and biology,
T M Wilkie, and
D J Gilbert, and
A S Olsen, and
X N Chen, and
T T Amatruda, and
J R Korenberg, and
B J Trask, and
P de Jong, and
R R Reed, and
M I Simon
January 2000,
Yeast (Chichester, England),
