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The action of a high molecular weight peptidoglycan produced by Agrobacter radiobacter sp. on the functional activity parameters in leukocytes and macrophages i. e. chemotaxis and adhesion was studied. It was shown that the peptidoglycan had a stimulating action on the chemotaxis of cells of the peritoneal exudate. A marked stimulating action of the drug on the primary immune response to the tissue antigen of sheep erythrocytes was observed. The peptidoglycan stimulated the antibody titers and delayed hypersensitivity when administered in various periods after an antigenic stimulus. Multifactorial experiments on the protective action of the peptidoglycan in experimental infections were carried out. Second-order polynomial statistic models characterizing the animal survival rate were constructed and the dose-time parameters of the drug use were optimized.
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
November 1999,
Preparative biochemistry & biotechnology,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
January 1984,
Farmakologiia i toksikologiia,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
January 1982,
Annali dell'Istituto superiore di sanita,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
January 1997,
Vestnik Rossiiskoi akademii meditsinskikh nauk,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
December 1989,
Kanagawa shigaku. The Journal of the Kanagawa Odontological Society,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
January 1992,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
January 1999,
Vestnik Rossiiskoi akademii meditsinskikh nauk,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
January 1986,
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
September 1942,
Journal of bacteriology,
A V Nikitin, and
L P Ivanitskaia, and
T V Smolkina, and
A I Zebrev, and
A N Lobuseva
January 1991,
Medicinal research reviews,
