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Effect of PGE2 on interleukin-1 and superoxide release from primary-cultured human hepatic macrophages. 1992
N Funaki, and
S Arii, and
Y Adachi, and
H Higashituji, and
S Fujita, and
M Furutani, and
M Mise, and
S Ishiguro, and
T Kitao, and
J Tanaka
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
In order to learn more about how human hepatic macrophages function, we analyzed the effect of exogenous PGE2 on the amounts of interleukin-1 (IL-1) and superoxide (O2-) released from primary-cultured human hepatic macrophages (HHM phi). When endogenous PGE2 production was blocked by indomethacin, exogenous PGE2 reduced IL-1 release from HHM phi in a dose-dependent manner, whereas it tended to increase O2- release from HHM phi. These results may suggest the probable contribution of PGE2 in regulating HHM phi mediator release in vivo.
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