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Prekallikrein, plasminogen and prothrombin of human blood plasma have been separately activated by caolin streptokinase and thromboplastin. By measuring the TAME-esterase (N-d Tozy-L-arginine methyl ester) activity of each enzyme and its changes in the course of plasma incubation with the activator, it was possible to estimate the values of precursors of kallikrein, plasmin, thrombin and their inhibitors. Evidence is given that under conditions described the activation is specific of each enzyme and does not affect the level of the two other percursors. The method has been developed in two modifications, permitting to obtain the value of seven parameters in 0.4--0.7 ml of blood plasma.
O A Gomazkov, and
N V Komissarova
August 1985,
Vrachebnoe delo,
O A Gomazkov, and
N V Komissarova
December 1962,
Canadian journal of biochemistry and physiology,
O A Gomazkov, and
N V Komissarova
January 1974,
Ukrains'kyi biokhimichnyi zhurnal,
O A Gomazkov, and
N V Komissarova
October 1977,
Biochimica et biophysica acta,
O A Gomazkov, and
N V Komissarova
October 1981,
Biochimica et biophysica acta,
O A Gomazkov, and
N V Komissarova
November 2001,
Chemical & pharmaceutical bulletin,
O A Gomazkov, and
N V Komissarova
January 1965,
Enzymologia biologica et clinica,
O A Gomazkov, and
N V Komissarova
May 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
O A Gomazkov, and
N V Komissarova
April 1983,
Kardiologiia,
O A Gomazkov, and
N V Komissarova
April 1972,
Biochimica et biophysica acta,
