In vivo exposure to ultraviolet radiation enhances pathogenic effects of murine leukemia virus, LP-BM5, in murine acquired immunodeficiency syndrome. 1992

C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
Photomedicine Program, Lovelace Medical Foundation, Albuquerque, NM 87108.

LP-BM5 murine leukemia virus (MuLV) induces an immunodeficiency syndrome (MAIDS) in C57BL/6 mice which resembles immunological abnormalities observed in early stages of human AIDS. In our study, MAIDS virus-infected mice were exposed to low doses of ultraviolet radiation (UVR) before and after virus inoculation and compared with MAIDS-infected but not UVR-exposed mice. In all tested parameters (blood IgM levels; mitogenic responses to PHA, ConA, LPS and anti-mu; MLR; antigenic response to SRBC; enlargement and histopathologic changes of the spleen) we observed the same trend: changes due to MAIDS infection were more pronounced in the UVR-exposed group than in the unexposed group. Statistically significant differences between these two groups were seen for mitogenic responses at two different time points after virus inoculation. These results demonstrate that in vivo UVR exposure enhances the immunosuppressive effects of a retroviral infection. UVR exposure may affect the progression of AIDS in a similar manner.

UI MeSH Term Description Entries
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008808 Mice, Inbred CBA An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH. Mice, CBA,Mouse, CBA,Mouse, Inbred CBA,CBA Mice,CBA Mice, Inbred,CBA Mouse,CBA Mouse, Inbred,Inbred CBA Mice,Inbred CBA Mouse
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009052 Leukemia Virus, Murine Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. Graffi Virus,Graffi's Chloroleukemic Strain,Leukemia Viruses, Murine,Mouse Leukemia Viruses,Murine Leukemia Virus,Murine Leukemia Viruses,Graffi Chloroleukemic Strain,Graffis Chloroleukemic Strain,Leukemia Viruses, Mouse
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014466 Ultraviolet Rays That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants. Actinic Rays,Black Light, Ultraviolet,UV Light,UV Radiation,Ultra-Violet Rays,Ultraviolet Light,Ultraviolet Radiation,Actinic Ray,Light, UV,Light, Ultraviolet,Radiation, UV,Radiation, Ultraviolet,Ray, Actinic,Ray, Ultra-Violet,Ray, Ultraviolet,Ultra Violet Rays,Ultra-Violet Ray,Ultraviolet Black Light,Ultraviolet Black Lights,Ultraviolet Radiations,Ultraviolet Ray
D016183 Murine Acquired Immunodeficiency Syndrome Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas. AIDS, Murine,MAIDS,Murine AIDS,Murine Acquired Immune Deficiency Syndrome,Murine Acquired Immuno-Deficiency Syndrome,AIDSs, Murine,Murine AIDSs,Murine Acquired Immuno Deficiency Syndrome

Related Publications

C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
January 2016, Immunological investigations,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
August 2015, Journal of medicinal food,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
December 1994, International immunology,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
January 1992, Regional immunology,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
March 1992, The Journal of nutrition,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
January 1992, Life sciences,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
February 1991, Transplantation proceedings,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
October 1998, Journal of neurovirology,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
January 2001, Pathobiology : journal of immunopathology, molecular and cellular biology,
C M Brozek, and G M Shopp, and S L Ryan, and P M Gillespie, and D F Kusewitt, and M S Rajagopalan, and K D Ley, and R D Ley
April 1996, Infection and immunity,
Copied contents to your clipboard!