Immunomodulatory and Antioxidant Effects of Purple Sweet Potato Extract in LP-BM5 Murine Leukemia Virus-Induced Murine Acquired Immune Deficiency Syndrome. 2015

Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
1 Department of Medical Nutrition, Kyung Hee University , Yongin, Korea.

The immunomodulatory effects of a dietary supplement of purple sweet potato extract (PSPE) in LP-BM5 murine leukemia virus (MuLV)-induced immune-deficient mice were investigated. Mice were divided into six groups: normal control, infected control (LP-BM5 MuLV infection), positive control (LP-BM5 MuLV infection+dietary supplement of red ginseng 300 mg/kg), purple sweet potato water extract (PSPWE) (LP-BM5 MuLV infection+dietary supplement of PSPE 300 mg/kg), PSP10EE (LP-BM5 MuLV infection+dietary supplement of 10% ethanol PSPE 300 mg/kg), and PSP80EE (LP-BM5 MuLV infection+dietary supplement of 80% ethanol PSPE 300 mg/kg). Dietary supplementation began on the day of LP-BM5 MuLV infection and continued for 12 weeks. Dietary supplementation of PSPE inhibited LP-BM5 MuLV-induced splenomegaly and lymphadenopathy and attenuated the suppression of T- and B-cell proliferation and T helper 1/T helper 2 cytokine imbalance in LP-BM5 MuLV-infected mice. Dietary supplement of PSPE increased the activity of the antioxidant enzymes, superoxide dismutase and glutathione peroxidase. The data suggest that PSPE may ameliorate immune dysfunction due to LP-BM5 MuLV infection by modulating antioxidant defense systems.

UI MeSH Term Description Entries
D008206 Lymphatic Diseases Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS. Lymphatism,Status Lymphaticus,Disease, Lymphatic,Diseases, Lymphatic,Lymphatic Disease
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009052 Leukemia Virus, Murine Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. Graffi Virus,Graffi's Chloroleukemic Strain,Leukemia Viruses, Murine,Mouse Leukemia Viruses,Murine Leukemia Virus,Murine Leukemia Viruses,Graffi Chloroleukemic Strain,Graffis Chloroleukemic Strain,Leukemia Viruses, Mouse
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005979 Glutathione Peroxidase An enzyme catalyzing the oxidation of 2 moles of GLUTATHIONE in the presence of HYDROGEN PEROXIDE to yield oxidized glutathione and water. Cytosolic Glutathione Peroxidase,Glutathione Lipoperoxidase,Selenoglutathione Peroxidase,Glutathione Peroxidase, Cytosolic,Lipoperoxidase, Glutathione,Peroxidase, Glutathione,Peroxidase, Selenoglutathione
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D013163 Splenomegaly Enlargement of the spleen. Enlarged Spleen,Spleen, Enlarged

Related Publications

Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
September 1992, Photochemistry and photobiology,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
July 2018, Journal of medicinal food,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
October 2003, Archives of pharmacal research,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
January 1992, Regional immunology,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
February 2019, International journal of biological macromolecules,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
January 1991, Advances in experimental medicine and biology,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
December 1996, Brain research,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
February 2010, Animal science journal = Nihon chikusan Gakkaiho,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
December 1994, International immunology,
Ok-Kyung Kim, and Da-Eun Nam, and Ho-Geun Yoon, and Sun Jung Baek, and Woojin Jun, and Jeongmin Lee
January 1992, Life sciences,
Copied contents to your clipboard!