[Generation of superoxide anion and lipid peroxidation in serum of gout patients]. 1992

A P Agureev, and E I Sinauridze, and M S Tiurin, and S S Nikitina, and N V Guliaeva

Alterations in content of lipid peroxidation products, reactions of generation/interception of superoxide anion radicals, content of R-proteins and uric acid were studied in blood serum of 83 patients with gout depending on the disease activity. Rates of lipid peroxidation, estimated by content of thiobarbituric acid-positive products, and of superoxide anion generation as well as content of R-proteins correlated distinctly with activity of the inflammation. At the same time, content of uric acid in blood serum of these patients correlated reversely with content of the lipid peroxidation products at the disease preexacerbation period, while concentration of these products depended on content of total iron.

UI MeSH Term Description Entries
D005609 Free Radicals Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. Free radicals include reactive oxygen and nitrogen species (RONS). They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated. Free Radical
D006073 Gout Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi. Gouts
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000838 Anions Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis. Anion
D013481 Superoxides Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides. Superoxide Radical,Superoxide,Superoxide Anion
D014155 Transcobalamins A group of carrier proteins which bind with VITAMIN B12 in the BLOOD and aid in its transport. Transcobalamin I migrates electrophoretically as a beta-globulin, while transcobalamins II and III migrate as alpha-globulins. Cobalamin-Binding Protein,Transcobalamin,Transcobalamin II,Vitamin B 12-Binding Protein,Vitamin B 12-Binding Proteins,Vitamin B12-Binding Protein,Cobalamin-Binding Proteins,Cobalophilin,Haptocorrin,Holo-Transcobalamin II,R-Binder,Transcobalamin (I),Transcobalamin I,Transcobalamin III,Vitamin B 12 Binder,Vitamin B12-Binding Proteins,B12-Binding Protein, Vitamin,Cobalamin Binding Protein,Cobalamin Binding Proteins,Holo Transcobalamin II,Protein, Cobalamin-Binding,Protein, Vitamin B12-Binding,Proteins, Cobalamin-Binding,Proteins, Vitamin B12-Binding,R Binder,Vitamin B 12 Binding Protein,Vitamin B 12 Binding Proteins,Vitamin B12 Binding Protein,Vitamin B12 Binding Proteins
D014527 Uric Acid An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN. 2,6,8-Trihydroxypurine,Ammonium Acid Urate,Monosodium Urate,Monosodium Urate Monohydrate,Potassium Urate,Sodium Acid Urate,Sodium Acid Urate Monohydrate,Sodium Urate,Sodium Urate Monohydrate,Trioxopurine,Urate,Acid Urate, Ammonium,Acid Urate, Sodium,Acid, Uric,Monohydrate, Monosodium Urate,Monohydrate, Sodium Urate,Urate Monohydrate, Monosodium,Urate Monohydrate, Sodium,Urate, Ammonium Acid,Urate, Monosodium,Urate, Potassium,Urate, Sodium,Urate, Sodium Acid
D015227 Lipid Peroxidation Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor. Lipid Peroxidations,Peroxidation, Lipid,Peroxidations, Lipid

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