-transparent.png){kind=logo}
Retinoidal activity of retinoic acid isomers [all-trans-retinoic acid (ATRA), 9-cis-retinoic acid (9CRA) and 13-cis-retinoic acid (13CRA)] and their oxidized derivatives [19-hydroxy and 19-oxo derivatives of ATRA (19-hydroxy-ATRA and 19-oxo-ATRA), 19-oxo derivative of 9CRA (19-oxo-9CRA), and 19-hydroxy derivative of 13CRA (19-hydroxy-13CRA)] was evaluated by means of a human promyelocytic leukemia HL-60 cell differentiation induction assay. All the compounds examined showed this activity with ED50 values of 2-30 nM, which are in accordance with their binding activity to nuclear retinoic acid receptors (RARs).
Related Publications
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
April 1981,
Experientia,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
December 1984,
Journal of pharmacobio-dynamics,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
February 1998,
Oncogene,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
May 1980,
Proceedings of the National Academy of Sciences of the United States of America,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
April 1987,
European journal of haematology,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
April 1985,
The Journal of biological chemistry,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
January 2004,
Yao xue xue bao = Acta pharmaceutica Sinica,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
July 2014,
Natural product communications,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
May 2001,
European journal of pharmacology,
Y Matsushima, and
E Kawachi, and
H Tanaka, and
H Kagechika, and
Y Hashimoto, and
K Shudo
January 1993,
Life sciences,
