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Three of 14 cynomolgus monkeys given the highest dose of an immunosuppressive drug in a 6-month toxicology study developed B virus (Herpesvirus simiae) oral lesions after 3 months of dosing. This necessitated early removal of all high-dose monkeys from the study due to concerns related to B virus. The incidence and severity of parasitic (Oesphagostomum sp.) lesions of the large intestine were also increased in high-dose animals. Both B virus and Oesophagostomum are enzootic in macaques, and the lesions caused by them were considered secondary to chronic immunosuppression caused by the highest dose of the test compound. Evidence of immunosuppression included decreased lymphocyte counts (B-cells; CD2 and CD8 T-cells), histopathologic evidence of lymphoid suppression, and serum-induced inhibition of lymphocyte mitogen responses. Pathogenesis of the B virus was apparently associated with both activation of latent virus as well as transmission of active virus. Approaches for virologic monitoring of primates and for ensuring optimal safety for primate handlers are discussed.
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
August 1991,
Laboratory animal science,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
January 1987,
Journal of medical primatology,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
May 1995,
International journal of cancer,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
October 1986,
Acta pathologica japonica,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
September 1989,
Archives of dermatology,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
May 1988,
The Journal of infectious diseases,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
December 1981,
British medical journal (Clinical research ed.),
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
October 1963,
The Cornell veterinarian,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
November 1966,
Acta virologica,
G J Chellman, and
V S Lukas, and
E M Eugui, and
K P Altera, and
S J Almquist, and
J K Hilliard
October 1994,
Laboratory animal science,
