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Four cynomolgus monkeys (Macaca fascicularis) were inoculated in the lips and tongues with B virus. Virus shedding and antibody responses were monitored for up to 50 days postinfection. Virus was isolated from the oral cavities of all monkeys at 6 days postinfection despite the absence of observable lesions. Virus was not isolated from genital swabs or serum. Antibodies to both B virus and herpes simplex virus were detected by neutralization between days 8 and 12. Virus-specific IgM and IgG antibodies were measured by antibody capture radioimmunoassay. IgM was first detected on day 6; by contrast, IgG did not appear until day 12. Antibodies reactive in a competitive radioimmunoassay appeared by day 12 and peaked at 30 to 40 days postinfection. This study provides data on which to base the diagnosis of primary B virus infection in cynomolgus monkeys.
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
April 1992,
Laboratory animal science,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
October 1994,
Laboratory animal science,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
September 1989,
Archives of dermatology,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
March 1980,
British medical journal,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
May 1988,
The Journal of infectious diseases,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
December 1981,
British medical journal (Clinical research ed.),
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
January 1989,
Antiviral research,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
April 1984,
European journal of clinical microbiology,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
January 1987,
Journal of medical primatology,
D N Lees, and
A Baskerville, and
L M Cropper, and
D W Brown
March 1966,
Acta virologica,
