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Urinary glycylprolyl dipeptidyl aminopeptidase (GP-DAP) concentrations were determined in 36 insulin-dependent diabetic children aged 4-18 years with a duration of diabetes ranging from 1 month to 14 years. Abnormal urinary GP-DAP concentrations were found in 19 of the 36 patients. Twelve of 27 patients without microalbuminuria also had increased urinary concentrations of GP-DAP. There was a significant correlation between urinary GP-DAP and plasma fructosamine (r = 0.52, p < 0.001). Our data suggest that urinary GP-DAP may be used as a marker for diabetic nephropathy. However, there is also a possibility that increased urinary GP-DAP concentrations are functionally related to poor metabolic control. Longitudinal studies are needed to establish the clinical usefulness of urinary GP-DAP.
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November 2004,
Nihon rinsho. Japanese journal of clinical medicine,
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January 1998,
Nihon rinsho. Japanese journal of clinical medicine,
O Nukada, and
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August 1999,
Nihon rinsho. Japanese journal of clinical medicine,
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February 1992,
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October 1983,
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December 1982,
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January 1987,
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June 1981,
Biochemical medicine,
O Nukada, and
M Kobayashi, and
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H Himei, and
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December 1990,
Nihon rinsho. Japanese journal of clinical medicine,
