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We have studied induction and repair of chromosome damage induced by high linear energy transfer (LET) heavy ions in G1/G0 interphase Syrian golden hamster embryo (SHE) cells as revealed by the premature chromosome condensation (PCC) technique. The number of chromosome breaks in condensed chromosomes induced by high LET heavy ions was higher than those induced by 137Cs gamma-rays. Compared with 137Cs gamma rays, the relative biological effectiveness (RBE) for PCC breaks was 1.5 for 35 keV/microns 4He ions, 1.9 for 77keV/microns 4He ions, and 2.5 for 530keV/microns 14N ions. Although 95% of the PCC breaks induced by gamma-rays rejoined during 8 h post-irradiation incubation, only 35-45% of fragments induced by high LET radiations rejoined in the same time. These results suggest that there is a difference, spatial or qualitative, in the initial chromosome damage produced by high LET radiations and low LET radiations.
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M Suzuki, and
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M Suzuki, and
M Watanabe, and
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M Suzuki, and
M Watanabe, and
K Suzuki, and
K Nakano, and
K Matsui
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M Suzuki, and
M Watanabe, and
K Suzuki, and
K Nakano, and
K Matsui
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M Suzuki, and
M Watanabe, and
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K Matsui
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M Suzuki, and
M Watanabe, and
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K Nakano, and
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M Suzuki, and
M Watanabe, and
K Suzuki, and
K Nakano, and
K Matsui
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International journal of radiation biology and related studies in physics, chemistry, and medicine,
M Suzuki, and
M Watanabe, and
K Suzuki, and
K Nakano, and
K Matsui
January 1987,
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M Suzuki, and
M Watanabe, and
K Suzuki, and
K Nakano, and
K Matsui
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Methods in molecular biology (Clifton, N.J.),
