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We have developed nuclear magnetic resonance (NMR) flow imaging techniques to measure fluid flow in a cell-free hollow fiber bioreactor (HFBR). Using 1H NMR we track the motion of protons and obtain velocity distributions as a function of position and time. These measurements enable the visualization of flow patterns needed for module design and for establishing desired operating conditions. Uneven flow in the cell-containing region of an HFBR can result in concentration gradients and uneven cell distribution that may lead to reduced cell viability. Results from this non-invasive method could be used to design more efficient cell bioreactors or membrane separation devices.
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C A Heath, and
S D Mirer, and
G Belfort
January 1984,
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B E Hammer, and
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G Belfort
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B E Hammer, and
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Science (New York, N.Y.),
B E Hammer, and
C A Heath, and
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G Belfort
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B E Hammer, and
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G Belfort
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B E Hammer, and
C A Heath, and
S D Mirer, and
G Belfort
August 2016,
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