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The combined effects of five cytokines; recombinant human (rHu) granulocyte colony-stimulating factor (G-CSF), rHu granulocyte-macrophage colony-stimulating factor (GM-CSF), rHu interleukin-1 beta (IL-1 beta), rHu interleukin-3 (IL-3), and rHu interleukin-6 (IL-6) on blast colony formation in methylcellulose by leukemic blast progenitors from 10 patients with acute myeloblastic leukemia (AML) were studied. Combination of G-CSF, GM-CSF, IL-1 beta, and IL-3 stimulated maximum blast colony formation in 9 patients. Further addition of IL-6 reduced the combined effect of the four cytokines on blast colony formation. IL-6 regulates the proliferation of leukemic blast progenitors and may play an important role in the regulation of hematopoiesis.
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
October 1990,
Japanese journal of cancer research : Gann,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
December 1997,
International journal of hematology,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
December 1992,
Japanese journal of cancer research : Gann,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
August 1989,
Leukemia,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
May 1986,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
January 1997,
Acta haematologica,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
July 1989,
Blood,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
August 1988,
Blood,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
January 1990,
Acta haematologica,
T Suzuki, and
M Bessho, and
K Hirashma, and
S Tohda, and
K Nagata, and
Y Imai, and
N Nara
November 1988,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
