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Several parameters of chlorin e6 and its derivative chlorin e6 ethylenediamide have been investigated as these compound are potential sensitizers for photodynamic therapy. A study carried out to compare the cellular uptake of the pigments indicates that chlorin e6 ethylenediamide possesses an enhanced affinity for tumour cells and cellular membranes. Comparison of the uptake in induced sarcoma shows that chlorin e6 ethylenediamide is a much better tumour localizer than chlorin e6. The efficiency of phototherapy with chlorin e6 ethylenediamide is higher than that with chlorin e6. These data show the influence of the substitution of the carboxyl groups in chlorin e6 by ester and amide groups on the photosensitizing properties of the pigments.
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
May 1988,
Journal of the National Cancer Institute,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
April 2019,
Journal of nanobiotechnology,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
January 2016,
International journal of nanomedicine and nanosurgery,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
March 1995,
Cancer research,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
September 2016,
Photodiagnosis and photodynamic therapy,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
March 2014,
Biochimica et biophysica acta,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
September 2015,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
February 2013,
Medicinal chemistry (Shariqah (United Arab Emirates)),
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
August 2019,
International journal of molecular sciences,
G P Gurinovich, and
T E Zorina, and
S B Melnov, and
N I Melnova, and
I F Gurinovich, and
L A Grubina, and
M V Sarzhevskaya, and
S N Cherenkevich
November 1992,
Journal of immunological methods,
