Synthesis and in-vitro photodynamic studies of the superparamagnetic chitosan hydrogel/chlorin E6 nanocarriers. 2013

Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
Nanostructured Materials Synthesis Lab., International Research Institute of Arian Chemie Gostar, Tabriz, Iran.

The objective of the present study was to develop superparamagnetic chitosan(CS) � dextran sulfate(DS) hydrogels as a intelligent drug system for effective carrying of Chlorin E6(chn E6) photosensitizer to cancer cells. This system can be detectable by magnetic Resonance Imaging technique. The study shows that the lifetime of the triplet state for chn E6 photosensitizer is significantly increase when encapsulate into hydrogel. In addition to the possible enhancement of 1O2 generation, other advantages to incorporating chn E6 -based PS agents into hydrogel include the ability to solubilize these generally hydrophobic agents, the small and uniform size of hydrogels, and potential for passive targeting of solid tumors via the enhanced permeation and retention effect decreasing systemic photosensitization.

UI MeSH Term Description Entries
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D008280 Magnetics The study of MAGNETIC PHENOMENA. Magnetic
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D010316 Particle Size Relating to the size of solids. Particle Sizes,Size, Particle,Sizes, Particle
D011166 Porphyrins A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin. Porphyrin
D002214 Capsules Hard or soft soluble containers used for the oral administration of medicine. Capsule,Microcapsule,Microcapsules
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D002735 Chlorophyllides Products of the hydrolysis of chlorophylls in which the phytic acid side chain has been removed and the carboxylic acids saponified. Chlorophyllide
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
April 1992, Journal of photochemistry and photobiology. B, Biology,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
May 1988, Journal of the National Cancer Institute,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
February 2021, Journal of biomedical nanotechnology,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
September 2019, Colloids and surfaces. B, Biointerfaces,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
March 2018, ACS applied materials & interfaces,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
June 2018, ACS applied materials & interfaces,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
September 2016, Photodiagnosis and photodynamic therapy,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
May 2018, ACS applied materials & interfaces,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
January 2016, International journal of nanomedicine and nanosurgery,
Mohammad Reza Saboktakin, and Roya M Tabatabaie, and Fahimeh Satarzade Amini, and Abel Maharramov, and Mohammad Ali Ramazanov
December 1999, Investigative ophthalmology & visual science,
Copied contents to your clipboard!