-transparent.png){kind=logo}
OBJECTIVE Injection of arginine vasopressin into the cerebral ventricles in animals with brain injury increased brain water, whereas injection of atrial natriuretic peptide reduced water content. Therefore, to determine the role of endogenous arginine vasopressin in brain edema, we attempted to inhibit edema from a hemorrhagic lesion with an arginine vasopressin V1 receptor antagonist or atrial natriuretic peptide. METHODS Adult Sprague-Dawley rats with hemorrhages induced by 0.4 IU bacterial collagenase were treated with 75 ng (n = 9) or 8 micrograms (n = 9) of the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)Arg, 3.2 micrograms (n = 4) atrial natriuretic peptide injected intracerebrally, or 5 micrograms/kg per hour (n = 7) atrial natriuretic peptide intraperitoneally. They were compared with control groups injected with 0.4 IU collagenase only. Brain water and electrolytes were measured 24 hours later. Brain uptake of [14C]sucrose was measured 30 minutes after lesions were induced by 0.4 IU collagenase alone (n = 5) or after collagenase injection and 50 micrograms/kg per hour (n = 5) atrial natriuretic peptide injected intravenously. RESULTS The arginine vasopressin V1 receptor antagonist and atrial natriuretic peptide significantly (p < 0.05) reduced water and sodium contents in the posterior edematous regions. Brain uptake of [14C]sucrose was significantly reduced by intravenous atrial natriuretic peptide. CONCLUSIONS Antagonists to arginine vasopressin V1 receptors and atrial natriuretic peptide both significantly reduce hemorrhagic brain edema, and atrial natriuretic peptide appears to protect the blood-brain barrier.
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
January 1999,
Neurosurgery,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
September 2001,
Neurosurgery,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
May 1995,
Stroke,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
January 1997,
Acta neurochirurgica. Supplement,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
March 1989,
The American journal of physiology,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
August 1993,
Acta psychiatrica Scandinavica,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
January 1988,
Nephron,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
July 1988,
Clinical science (London, England : 1979),
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
May 1988,
Clinical chemistry,
G A Rosenberg, and
O Scremin, and
E Estrada, and
W T Kyner
January 2013,
Neuropsychobiology,
