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Rapid and efficient synthesis of 1H-indol-2-yl-1H-quinolin-2-ones. 2003

Jeffrey T Kuethe, and Audrey Wong, and Ian W Davies
Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA.

[reaction: see text] A concise and efficient synthesis of the novel indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitors 1-3 is presented.

UI MeSH Term Description Entries

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