Improved Method for Preparation of 3-(1H-Indol-3-yl)benzofuran-2(3H)-ones. 2022

Igor Yu Grishin, and Nikolai A Arutiunov, and Dmitrii A Aksenov, and Nicolai A Aksenov, and Alexander V Aksenov, and Amina Z Gasanova, and Elena A Sorokina, and Carolyn Lower, and Michael Rubin
Department of Chemistry and Pharmacy, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.

3-(1H-Indol-3-yl)benzofuran-2(3H)-ones were efficiently accessed via polyphosphoric acid-mediated condensation of 3-(2-nitrovinyl)-1H-indoles with phenols.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D010636 Phenols Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D001572 Benzofurans Compounds that contain a BENZENE ring fused to a furan ring. Coumarones,Diphenylbenzofuran

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