BIOMAT Database Logo BIOMAT Database Logo

Phosphorodiamides as prodrugs for antiviral nucleosides. 2003

Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. aal@imb.ac.ru

New phosphorodiamides of modified nucleoside monophosphates were synthesized and their antiviral properties were evaluated.

UI MeSH Term Description Entries
D009711 Nucleotides The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Nucleotide
D010766 Phosphorylation The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety. Phosphorylations
D011355 Prodrugs A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. Drug Precursor,Drug Precursors,Pro-Drug,Prodrug,Pro-Drugs,Precursor, Drug,Precursors, Drug,Pro Drug,Pro Drugs
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D015215 Zidovudine A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. AZT (Antiviral),Azidothymidine,3'-Azido-2',3'-Dideoxythymidine,3'-Azido-3'-deoxythymidine,AZT Antiviral,AZT, Antiviral,BW A509U,BWA-509U,Retrovir,3' Azido 2',3' Dideoxythymidine,3' Azido 3' deoxythymidine,Antiviral AZT,BWA 509U,BWA509U
D015497 HIV-1 The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte. Human immunodeficiency virus 1,HIV-I,Human Immunodeficiency Virus Type 1,Immunodeficiency Virus Type 1, Human
D017553 Phosphorus Compounds Inorganic compounds that contain phosphorus as an integral part of the molecule. Compounds, Phosphorus
D018119 Stavudine A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. 2',3'-Didehydro-3'-deoxythymidine,D4T,2',3'-Didehydro-2',3'-dideoxythmidine,BMY-27857,Stavudine, Monosodium Salt,Zerit,2',3' Didehydro 3' deoxythymidine,BMY 27857,BMY27857
D018259 Herpesvirus 1, Human The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions. HSV-1,Herpes Simplex Virus 1,HHV-1,Herpes Simplex Virus Type 1,Herpesvirus 1 (alpha), Human,Human Herpesvirus 1

Related Publications

Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
New prodrugs of acyclic nucleosides with antiviral activity.
November 1988, Arzneimittel-Forschung,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy.
July 2017, Antiviral research,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials.
October 2020, The Journal of antimicrobial chemotherapy,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Synthesis of prodrugs as bridged nucleosides.
October 1998, Acta chemica Scandinavica (Copenhagen, Denmark : 1989),
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Acyclic nucleosides as antiviral compounds.
April 1996, Molecular biotechnology,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.
January 2013, European journal of medicinal chemistry,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides.
September 2013, European journal of medicinal chemistry,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Fluorinated nucleosides as antiviral and antitumor agents.
January 2006, Current topics in medicinal chemistry,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Metabolism of Nucleosides and Nucleotides Prodrugs.
October 2017, Current pharmaceutical design,
Alexander V Shipitsyn, and Natalya F Zakirova, and Evgeny F Belanov, and Tatyana R Pronyaeva, and Nina V Fedyuk, and Marina K Kukhanova, and Andrey G Pokrovsky
Synthesis of carbocyclic nucleosides as potential antiviral agents.
January 2001, Nucleic acids research. Supplement (2001),
Copied contents to your clipboard!