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More than 130 acyclic purine and pyrimidine nucleoside derivatives have been synthesized. Structure-activity relationships among a selected group of 6- and 9-substituted guanine derivatives will be discussed. By introduction of secondary aliphatic (e.g. isopropyl or secondary butyl) ether groups into acyclic nucleosides such as aciclovir and ganciclovir new lipophilic prodrugs with modified physical and improved pharmacokinetic properties have been obtained. Several compounds with isopropylether groups in the side-chain and/or in the 6-position (among these the 6-deoxy derivative Hoe 602) of the purine moiety displayed excellent antiviral activity when tested in vivo against herpes simplex virus type 1 infection in mice.
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
July 2017,
Antiviral research,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
February 2010,
Archives of pharmacal research,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
September 2017,
Bioorganic & medicinal chemistry,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
September 2013,
European journal of medicinal chemistry,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
April 1996,
Molecular biotechnology,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
July 2017,
Molecules (Basel, Switzerland),
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
June 2018,
Acta chimica Slovenica,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
January 2003,
Nucleosides, nucleotides & nucleic acids,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
June 2008,
Chemical & pharmaceutical bulletin,
E Winkelmann, and
I Winkler, and
H Rolly, and
M Rösner, and
G Jähne
January 2005,
Nucleosides, nucleotides & nucleic acids,
