BIOMAT Database Logo BIOMAT Database Logo

Oligomerization aiming at phosphonate analogues of oligoadenylates. 2003

Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.

This work deals with isopolar, phosphonate-based nucleotide analogues containing a bridging P-C bond instead of the ester P-O linkage. Specifically, starting from activated derivatives 1, 2, and 3, a simple process for preparation of mixtures of short oligomers and their analyses were elaborated.

UI MeSH Term Description Entries
D007202 Indicators and Reagents Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499) Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D009843 Oligoribonucleotides A group of ribonucleotides (up to 12) in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
D000227 Adenine Nucleotides Adenine Nucleotide,Adenosine Phosphate,Adenosine Phosphates,Nucleotide, Adenine,Nucleotides, Adenine,Phosphate, Adenosine,Phosphates, Adenosine
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D016047 Zalcitabine A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. 2',3'-Dideoxycytidine,Dideoxycytidine,ddC (Antiviral),HIVID Roche,Hivid,NSC-606170,2',3' Dideoxycytidine,NSC 606170,NSC606170
D063065 Organophosphonates Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P Phosphonate,Phosphonates,Phosphonic Acid Esters,Acid Esters, Phosphonic,Esters, Phosphonic Acid

Related Publications

Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Activation of murine RNase L by isopolar 2'-phosphonate analogues of 2',5' oligoadenylates.
June 2006, Journal of medicinal chemistry,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
5'-Phosphonate modified oligoadenylates as potent activators of human RNase L.
February 2022, Bioorganic & medicinal chemistry,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Phosphonate analogues of aminoacyl adenylates.
November 1978, The Biochemical journal,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Synthesis of lipid II phosphonate analogues.
September 2011, Carbohydrate research,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Enzyme inhibition by phosphonate analogues of dTTP.
January 1984, Advances in experimental medicine and biology,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Characterization and biological activity of 8-substituted analogues of 2',5'-oligoadenylates.
March 1993, Biochimica et biophysica acta,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Isosteric phosphonate pyrrolidine-based dinucleoside monophosphate analogues.
January 2003, Nucleosides, nucleotides & nucleic acids,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Phosphonate-phospholipid analogues inhibit human phospholipase A2.
September 1991, Agents and actions,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Synthesis and biological evaluation of phosphonate analogues of nevirapine.
March 2013, Bioorganic & medicinal chemistry letters,
Martina Pressová, and Radek Liboska, and Milos Budesínský, and Sárka Králíková, and Ivana Kavenová, and Ivan Rosenberg
Phosphonate analogues of triacylglycerols are potent inhibitors of lipase.
October 1995, Biochimica et biophysica acta,
Copied contents to your clipboard!