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31P NMR spectroscopy was used to assess the cerebral ischemia status in rats by measuring the relative levels of phosphate metabolites. Partial cerebral ischemia was induced in 49 rats by reversible occlusion of the carotid arteries. Rats were intubated and mechanically ventilated on a hypoxic gas mixture. Physiological parameters such as temperature and arterial pressure were strictly controlled during the experiments. 31P spectra were acquired at 7 T during basal observation, for 15-20 min after the induction of ischemia, and for 1 hr after reperfusion. Depletion and increase in PCr and Pi levels, respectively, were already observable in the collected spectra within few minutes after the onset of ischemia. No appreciable changes were found in the ATP levels.
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
June 1991,
British journal of cancer,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
April 1994,
Brain research,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
December 1996,
Neuroreport,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
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B Maraviglia
April 1990,
NMR in biomedicine,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
January 1990,
Magnetic resonance in medicine,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
May 1983,
Proceedings of the National Academy of Sciences of the United States of America,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
April 1987,
Biochemical and biophysical research communications,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
May 1993,
The American journal of physiology,
M A Macrì, and
R Campanella, and
G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
October 1987,
Magnetic resonance in medicine,
M A Macrì, and
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G Garreffa, and
M Occhigrossi, and
F De Luca, and
E Arrigoni Martelli, and
B Maraviglia
July 1986,
Cancer biochemistry biophysics,
